Gather all ingredients and preheat the oven to 350 degrees F (175 degrees C).

Mix bread crumbs, Romano cheese, parsley, salt, pepper, garlic powder, and onion powder together in a large bowl; stir in water and eggs.

Add ground beef and mix until well combined.

Form mixture into balls and place on a nonstick baking sheet.

Bake in the preheated oven cooked through and evenly browned, about 30 minutes.

Serve and enjoy!