Gather all ingredients. Heat oil in a large, deep skillet to 350 degrees F (175 degrees C).

Combine flour, salt, pepper, paprika, and garlic powder in a large resealable plastic bag; mix well.

Pat chicken thighs dry with paper towels. Add to flour mixture in the plastic bag; seal the bag and shake until thoroughly coated.

Fry chicken in hot oil, turning occasionally, until deep golden brown, about 20 minutes. Drain on a paper towel-lined plate.