Preheat the oven to 350 degrees F (175 degrees C).

Mix ground beef, crackers, milk, pepper, salt, garlic powder, and Italian seasoning together in a large bowl until well combined. Form into eight large patties and place into a 9x13 inch baking dish. Pour condensed soup evenly over patties, then sprinkle canned mushrooms over top. Cover the pan with a lid or aluminum foil.

Bake in the preheated oven until patties are no longer pink in the center, about 45 minutes. An instant-read thermometer inserted into the center should read at least 160 degrees F (70 degrees C).