Preheat oven to 350 degrees F (175 degrees C). Grease a loaf pan.

Mix hamburger, tomatoes, green chiles, onion, milk, eggs, crackers, salt, and pepper together in a bowl. Transfer to the prepared loaf pan.

Bake in the preheated oven until until no longer pink in the center, about 1 hour and 10 minutes. An instant-read thermometer inserted into the center should read at least 160 degrees F (70 degrees C).

Let cool in the pan for 10 minutes before transferring to a serving dish.