Gather all ingredients.

Bring a large pot of lightly salted water to a boil. Add penne and cook, stirring occasionally, until tender yet firm to the bite, 8 to 10 minutes.

While the pasta is cooking, add oil and garlic to a large skillet over low heat. Cook until oil is hot and garlic is sizzling, 8 to 12 minutes. Remove from the heat and stir in parsley, basil, oregano, and pepper flakes.

Drain pasta and transfer to a large bowl. Add oil and garlic mixture, toss to coat, and let sit for 3 to 5 minutes. Sprinkle with Parmesan and serve.