Preheat the oven to 300 degrees F (150 degrees C).

Mix butter, Worcestershire sauce, red pepper, salt, and garlic powder together in a medium bowl; stir in pecans. Add chili powder and gently toss to coat. Spread coated pecans on a medium baking sheet.

Bake pecans in the preheated oven, checking and stirring every 8 to 10 minutes, until crispy around the edges, about 30 minutes, Best served warm.